
个人简介:
刘中华,男,39岁,硕博阶段于中山大学主要从事量子点投递siRNA靶向BACE1基因治疗阿尔茨海默病的研究,并发表SCI文章数篇。2011年以来,研究方向为开发新型智能响应性载体治疗阿尔茨海默病的研究。作为主要完成人参加多项国家自然科学基金(No. 31300884,No. 81271476)的研究工作。并于2014年获得河南大学省属高校基本科研业务费资助项目一项(资助经费25万元)和2016年河南省科技攻关项目一项(立项号:162102310074,资助10万元)。积累了较为丰富的纳米材料修饰、分子生物学和实验动物学的理论基础和实践经验,已在Biomaterials, Chem. Commun,Sensors and Actuators B 、J. Mater. Chem. C 、Mol Ther Nucleic Acids、current nanoscience等国内外学术期刊发表多篇学术论文。
教育工作经历:
2007/9 - 2011/7,中山大学,人体解剖学与组织胚胎学,博士,导师:李峰
2005/9 - 2007/7,中山大学,人体解剖学与组织胚胎学,导师:李峰
1997/9 - 2002/7,新乡医学院,临床医学,学士学位
2011/7 - 至今,河南大学,医学院,讲师
2002/7 - 2005/8,新乡医学院,医学院,助教
一、期刊论文
(11) Shengliang Li,† Qingyuan Deng,† Xiao Li, Yongwei Huang,* Xiaozhen Li, Fang Liu, Huijuan Wang, Weixia Qing, Zhonghua Liu,* and Chun-Sing Lee*, Bis-Diketopyrrolopyrrole Conjugated Polymer Nanoparticles as Photothermic Nanoagonist for Specific and Synergistic Glioblastoma Therapy, Biomaterials, 2019,119252. (SCI 一区, IF = 10.3)
(10) Qingyuan Deng, Enbao Zhou, Yongwei Huang,* Weixia Qing, Haiyan Zhai, Zhonghua Liu,* and Zhixiang Wei,* Chalcogen−substitution modulated supramolecular chirality and gas sensing properties in perylenediimides, Chem. Commun., 2019, 55, 4379–4382. (SCI一区,IF = 6.29).
(9) Zhonghua Liu, Fang Liu, Yijian Gao, Weixia Qing, Yongwei Huang,* Shengliang Li,* and Dongzhu Jin, AIEgen Nanoparticles of Arylamino Fumaronitrile Derivative with High Near-infrared emission for Two-photon Imaging and in vivo Cell Tracking, ACS Appl. Bio Mater., 2019, 2, 430–436.
8. Shasha Zhang, Xuejuan Wang, Yongwei Huang*, Haiyan Zhai, Zhonghua Liu*, “Ammonia sensing properties of perylene diimides: Effects of core-substituted chiral groups”, Sens. Actuators B, 2018, 254, 805-810. (SCI一区, IF = 5.4).
7. Yongwei Huang, Xiaotian Liu, Qing Wang, Jiya Fu*, Lili Zhao*, Zhonghua Liu* and Dongzhu Jin, “Highly responsive ethylenediamine vapor sensor based on perylenediimide–camphorsulfonic acid complex via ionic self-assembly”, J. Mater. Chem. C, 2017, 5, 7644 - 7651. (SCI一区, IF = 5.3).
6. Yongwei Huang, Xiaotian Liu, Qing Wang, Jiya Fu,* Lili Zhao,* Zhonghua Liu* and Dongzhu Jin. Highly responsive ethylenediamine vapor sensor based on a perylenediimide–camphorsulfonic acid complex via ionic self-assembly. J. Mater. Chem. C, 2017,5, 7644
5. 李想,金莹莹,刘一博,赵振,李晓,程方,刘中华*,黄永伟. 苝酰亚胺衍生物在肿瘤治疗中的应用进展. 有机化学.2017, 34 (6): 611-622
4. Fang Liu#, Xiang Li, Li-Yuan Zhang, Qing-Ru Song, Min Zhang, Chen-Xi Zhao, Jun Wang, Guo-tao Sun and Zhong-Hua Liu*,Stimuli-Responsive Nanocarriers for Drug Delivery to the Central Nervous System,Current Nanoscience, 12(1): 4-17.
3.Liu ZH, Li SL, Liang ZB, Zhao Y, Zhang YL, Yang YQ, Wang MJ, Li F. Targeting β-secretase with RNAi in neural stem cells for Alzheimer’sdisease therapy. Neural Regen Res. 2013;8(33):3095-3106
2. Shengliang Li, Zhonghua Liu, Fengtao Ji, Zijian Xiao, Minjuan Wang,Yingji Peng, Yulin Zhang, Ling Liu, Zibing Liang, Feng Li. Delivery of quantum dot-siRNA nanoplexes in SK-N-SH cells for BACE1 gene silencing and intracellular imaging. Mol Ther Nucleic Acids. 2012 Apr 24;1:e20. doi: 10.1038/mtna.2012.11.
1. Xiao Z, Lin L, Liu Z, Ji F, Shao W, Wang M, Liu L, Li S, Li F, Bu X. Potential therapeutic effects of curcumin: relationship to microtubule-associated proteins 2 in Aβ1-42 insult. Brain Res. ()2010 Nov 18;1361:115-23.
二、主持或参加科研项目(课题)及人才计划项目情况:
1.河南省科技发展计划项目,162102310074,脑靶向智能响应型纳米药物双载药物治疗阿尔茨海默病的探索,2015/12/31-2017/12/31,10万元,在研,主持
2.河南大学科研基金项目,xxjc20140019,量子点氧化石墨烯双载药系统靶向STAT3治疗胶质母细胞瘤的实验研究,2014/04/20-2019/04/20, 25万元,在研,主持
3.国家自然科学基金,21572045,手性烷基链调控下的苝酰亚胺衍生物自组装结构气敏传感性能研究, 2016.01-2019.12,78万,在研,参与。
三、专利:
(1)刘中华,刘芳,薛德明,李涛,高留州,谢玉锁,冯焱飞,闫强,吴书敏,倪礼礼,胡国强,手性7-(哌嗪取代的吡唑醛缩异烟肼腙)氟喹诺酮羧酸衍生物及其制备方法和应用,2016.5.28,中国,专利号:201410781139.4。
(2)黄永伟,刘中华,厉永强,刘笑天,王学娟, 一种含α-吡喃糖苷的苝酰亚胺衍生物及其制备方法和应用,申请日:2016,10,26,申请号:201610947932.6。
(3)黄永伟,张磊,刘中华,王学娟,张沙沙,一种含有S-构型樟脑磺酸的苝酰亚胺衍生物及其制备方法、应用,申请日:2017, 06, 02, 申请号:201710408408.6。